Pharmacokinetics of Thallous Chloride Tl 201 with no carrier added accumulates in viable myocardium in a manner analogous to that of potassium. Regions of transient myocardial ischemia corresponding to areas perfused by coronary arteries with partial stenoses have been visualized when Thallous Chloride Tl 201 was administered in conjunction with an exercise stress test. Advise patients to inform their physician or healthcare provider if they are pregnant or breast-feeding. STANDARD. J Nucl Med, 2005; 46(3), 502-508. Administer Thallous Chloride Tl 201 Injection to a pregnant woman only if clearly needed. Thallous Chloride Tl 201 Injection is supplied as a sterile, non-pyrogenic solution for intravenous administration. FDA Safety Recalls, Reversible defects (myocardial ischemia) when used in conjunction with exercise or pharmacologic stress. National Drug Codes 69945-0120 THALLOUS CHLORIDE Tl 201. Labeler Name: Curium Us Llc Radiation-absorbed dose from All Rights Reserved. The whole body disappearance half-time was 9.8 ± 2.5 days. TL-630 series. This table provides the basis for categorizing radionuclides according to relative hazard. Minimize close contact with infants if the administered dose would result in an effective dose greater than 1 mSv (0.1 rem) to the infant. 7.1 Pharmacology Thallous Chloride Tl-201 is the chloride salt form of thallium-201, a cyclotron produced isotope use in diagnostic imaging. Figure 1 shows maximum concentration of each radionuclidic contaminant as a function of time. (, Localization of sites of parathyroid hyperactivity pre- and post-operatively in patients with elevated serum calcium and parathyroid hormone levels. Minimize radiation exposure to the patient and ensure minimum radiation exposure to occupational workers. These highlights do not include all the information needed to use Thallous Chloride Tl 201 Injection safely and effectively. The pH is adjusted to between 4.5 to 7.0 with hydrochloric acid and/or sodium hydroxide. The dosimetry data in Table 1 reflect this distribution pattern and are based on a biological half-life of 2.4 days. WARNING: Radioactive drugs must be handled only by qualified personnel in conformity with regulation of the U.S. Nuclear Regulatory Commission or state regulatory agencies where applicable. When considering administration of Thallous Chloride Tl 201 Injection to women of child-bearing potential, consider the radiation risks for a fetus [see Use in Specific Populations (8.1)]. Blood clearance of Thallous Chloride Tl 201 is primarily by the myocardium, thyroid, liver, kidneys and stomach with the remainder distributing fairly uniformly throughout the body. Table 3. Table 4. The pH is adjusted to between 4.5 to 7.0 with hydrochloric acid and/or sodium hydroxide solution. Files, All Mapping For information on dosage, administration and indications see package insert. There are no adequate or well-controlled studies of Thallous Chloride Tl 201 Injection use in pregnant women. Thallous Chloride TI201 without carrier, accumulates in the heart (myocardium) in a similar way to that of potassium. (, Pediatrics: Safety and effectiveness have not been established in pediatric patients. ORDERING DEADLINES in rking days befre the shipent day CET. Thallous Chloride TI 201 Injection. Online radioactive decay calculator that allows you to find out the radioactivity decay in Thallium (Tl) 201. The estimated absorbed radiation doses at calibration time to a 70 kg patient from an intravenous injection of Thallous Chloride Tl 201 are shown in Table 1. Thallous Chloride, tl 201 injection, solution, We comply with the HONcode standard for trustworthy health information -, Drug class: diagnostic radiopharmaceuticals. Includes 10 keV x-rays4. The estimates were calculated based on human data from Krahwinkel et al.1and Thomas et al.2Assumed percentages of 98.3% 201Tl, 0.3% 200Tl, 1.2% 202Tl, and 0.2% 203Pb. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. Manufactured by: Curium US LLCMaryland Heights, MO 63043. and Thomas et al. The concentration of each radionuclidic contaminant changes with time. Table 1. Inject Thallous Chloride Tl 201 strictly intravenously to avoid local tissue accumulation and irradiation. Thallous Chloride Tl 201 is excreted slowly and to an equal extent in both feces and urine. 83(4):471-4753. See full prescribing information for Thallous Chloride Tl 201 Injection. Biodistribution is generally proportional to organ blood flow at the time of injection. Pharmacokinetics of thallium-201 in normal individuals after routine myocardial scintigraphy. Within two hours after the completion of the stress testing the target-to-background ratios may decrease in lesions that are attributable to transient ischemia. Biochemical Data Summary. The pH is adjusted to between 4.5 to 7.0 with hydrochloric acid and/or sodium hydroxide. Confirm intravenous patency before injection [see Adverse Reactions (. Thallous Chloride Tl 201 is excreted slowly and to an equal extent in both feces and urine. Aseptically withdraw the material for use with a shielded sterile syringe. Thallous Chloride Tl 201 Injection is a diagnostic radiopharmaceutical indicated for. 10/23/1979. 2Thomas SR, Stabin MG, Castronovo FP. Bottle containing drug should be kept in this container or within a heavier shield. Updated Thallous chloride TI-201 accumulates in myocardial cells and other tissues in an analogous way as potassium, and can be evaluated as a function of blood flow. Presence in Breast Milk, Medline Plus, 9 mg sodium chloride, and 0.9% (v/v) benzyl alcohol as a preservative. Myocardial perfusion imaging with planar scintigraphy or single-photon emission computed tomography (SPECT) for the diagnosis of coronary artery disease by localization of: Non-reversible defects (myocardial infarction), Reversible defects (myocardial ischemia) when used in conjunction with exercise or pharmacologic stress. Each milliliter contains 37 MBq (1 mCi) Thallous Chloride Tl 201 at calibration time, made isotonic with 9 milligrams sodium chloride and preserved with 0.9% (v/v) benzyl alcohol. J Nucl Med, 2005; 46(3), 502-508. Perform stress testing only under the supervision of a qualified physician and in a laboratory equipped with appropriate resuscitation and support equipment. Each milliliter contains 37 MBq (1 mCi) Thallous Chloride TI 201 (no carrier added) at date and time of calibration.
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